Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes

Summary

The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.

Eligibility

INCLUSION CRITERIA:

* female sex
* 18 -50 years old
* pregnancy history within 5 years of the study visit
* had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes
* or without a history of gestational diabetes

EXCLUSION CRITERIA:

* skin diseases
* current tobacco/e-cigarette use
* diagnosed or suspected hepatic or metabolic disease including diabetes
* statin or other cholesterol-lowering medication
* current antihypertensive medication
* history of preeclampsia or gestational hypertension
* current pregnancy
* body mass index \<18.5 kg/m2
* allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.

Conditions3

Locations1 site

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