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Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr

RECRUITINGN/ASponsored by Weill Medical College of Cornell University
Actively Recruiting
PhaseN/A
SponsorWeill Medical College of Cornell University
Started2024-02-26
Est. completion2028-12
Eligibility
Age18 Years+
SexMALE
Healthy vol.Accepted
Locations4 sites
View on ClinicalTrials.gov →

NCT05948657

Summary

This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermediate-risk prostate cancer.

Eligibility

Age: 18 Years+Sex: MALEHealthy volunteers accepted
Inclusion Criteria:

* Males aged ≥ 18.
* Histologically confirmed low or favorable intermediate risk prostate cancer per NCCN guidelines. (Note: Grade Group 2 must have 20% or less involvement in every core and no presence of cribiform or intraductal carcinoma).
* PSA \< 20 ng/ml.
* Ability to undergo yearly PSMA-PET CT.
* Ability to undergo yearly prostate mpMRI.
* Ability to undergo transrectal or transperineal template and fusion prostate biopsy.
* Willingness to undergo yearly prostate biopsies.

Exclusion Criteria:

* History of prior treatment for prostate cancer.
* History of systemic therapy for prostate cancer.
* Inability to undergo transrectal ultrasound.
* Life expectancy less than 10 years.
* Not interested in pursuing active surveillance.
* Initial diagnosis of prostate cancer greater than 15 months.

Conditions2

CancerProstate Cancer

Locations4 sites

California

2 sites
UCLA
Los Angeles, California, 90005
Sarah Yuansay7008@med.cornell.edu
UCSF
San Francisco, California, 94143
Sarah Yuansay7008@med.cornell.edu

New York

1 site
Weill Cornell Medicine - New York Presbyterian Hospital
New York, New York, 10065
Timothy McClure, M.D.tim9047@med.cornell.edu

Ohio

1 site
Case Western University Hospitals
Cleveland, Ohio, 44106
Matt FerrebeeMatt.Ferrebee@uhhospitals.org

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