Test of CD47-SIRPα Inhibitors on the Immune Microenvironment Colon Cancer

Summary

Our goal is to create novel CD47-SIRPα inhibitors using small molecules to reverse TAM-mediated immune suppression and restore anti-tumor immunity in CRCs. Our program uses structure-based drug design to create selective and potent small molecule inhibitors of SIRPα-CD47 to target the tumor microenvironment with greater efficacy and lower toxicity than CD47-targeting antibodies. . In order to study the activity of CD47-SIRPα inhibitors on the immune microenvironment of tumors, we propose to use organoids derived from biopsies of patients with colon cancer. Tumoroids preserve the patient's tumor stroma (including myeloid cells) and provide an accurate in vitro model of complex tumor immune interaction for the evaluation of immunotherapies.

Eligibility

Inclusion Criteria:

* Patient over 18 years old
* Patient who has signed a consent to participate;
* Patient with metastatic or non-metastatic colon cancer, or recurrence of colon cancer for whom excision surgery has been proposed;
* Patient affiliated to a social security scheme, or beneficiary of such a scheme

Exclusion Criteria:

* Patient who had emergency colon cancer surgery
* Person in an emergency situation or unable to express their consent.
* Adult subject to a legal protection measure (adult under guardianship, curatorship or safeguard of justice),
* Patient unable to submit to the medical follow-up of the trial for geographical, social or psychological reasons

Conditions2

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