Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest

Summary

Out-of-hospital cardiac arrest (OHCA) has multiple etiologies. In the absence of ST-elevation myocardial infarction, percutaneous coronary intervention (PCI) is delayed. This study aims to determine the diagnostic accuracy of Coronary Calcium Score (CCS) and Coronary CT Angiogram (CCTA) to rule out a coronary artery disease (CAD) in the first days after an OHCA.

Eligibility

Inclusion criteria :

* Patients hospitalized in intensive care unit after a resuscitated out-of-hospital cardiac arrest
* No obvious cause for sudden death on anamnestic information, CT brain and CT pulmonary angiogram.
* Absence of ST elevation myocardial infarction

Non-inclusion criteria :

* In-hospital cardiac arrest
* Refractory cardiac arrest
* Indication of immediate coronary angiography
* ST-elevation myocardial infarction or unknown left bundle branch block
* Dynamic or presumably new contiguous ST/T-segment changes
* Cardiogenic shock
* Life-threatening arrhythmias
* Coronary artery bypass graft
* Pregnancy
* Multiple organ failure syndrome
* Know severe chronic kidney disease (GFR \<30mL/min/1,73m²)

Exclusion criteria :

* During the Coronary computerized tomographic angiogram :
* Haemodynamic instability requiring high dose of vasopressors (\>1µg/kg/min of Norepinephrine)
* Non sinusal cardiac rhythm
* KDIGO 1 Acute kidney injury

Conditions2

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