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Identifying and Treating Depression in the Orthopaedic Trauma Population

RECRUITINGPhase 4Sponsored by Wake Forest University Health Sciences
Actively Recruiting
PhasePhase 4
SponsorWake Forest University Health Sciences
Started2025-06-25
Est. completion2026-05
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site

Summary

The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patients presenting to an Orthopaedic trauma clinic for the first time following operative extremity fracture or any pelvis fracture
* A score of greater than or equal to 5 on the Patient Health Questionnaire-9 (PHQ-9) at first post- operative visit
* Age 18 or older
* Speak English or Spanish

Exclusion Criteria:

* Currently taking medication to treat depression
* Contraindication/allergy to one of the study medications
* Bipolar disorder of psychotic disorder
* Endorse suicidal ideation

Conditions1

Depression

Locations1 site

Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Erica Grochowski, MPH704-403-4980Erica.Grochowski@atriumhealth.org

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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