Neoadjuvant Radiotherapy and Immediate Implant-Based Breast Reconstruction

Summary

Neoadjuvant radiotherapy(NART) followed by mastectomy and immediate DIEP flap reconstruction is feasible and technically safe. However, reports of NACT followed immediate implant-based breast reconstruction are rare. Some studies have shown that NART followed immediate implant-based breast reconstruction seems feasible and can be safely attempted. It's well known that radiotherapy after implant-based breast reconstruction have negative effects on implant and cosmetic results. So, investigators conducted a polit study to learn about acute post-surgical complications following skin-sparing mastectomy and immediate implant-based breast reconstruction after NART.

Eligibility

Inclusion Criteria:

Women \>18 years with histopathologically-confirmed breast cancer, who:

* require mastectomy for any reason
* a known indication for (adjuvant) radiotherapy
* require implant-based breast reconstruction

Exclusion Criteria:

* Inability to give informed consent
* MDT unable to make recommendation for radiotherapy based on pre-operative histopathological and imaging findings
* Previous history of breast cancer or another malignancy for which radiotherapy of the breast or axilla
* Pregnant or lactating
* inflammatory breast cancer

Conditions4

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