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Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

RECRUITINGSponsored by University of Michigan
Actively Recruiting
SponsorUniversity of Michigan
Started2023-09-06
Est. completion2027-09
Eligibility
Age14 Years – 18 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06007404

Summary

This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.

Eligibility

Age: 14 Years – 18 YearsHealthy volunteers accepted
Inclusion Criteria:

* Between 14 and 18 years of age
* Tanner stage 4 or 5 (mature adult stage of puberty)
* Normal weight (BMI ≥ 5th percentile \& \< 85th percentile), overweight (BMI \> 86th percentile) \& \< 94th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c \> 5.7%)
* For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes

Exclusion Criteria:

* Currently pregnant
* Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management
* Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff
* Allergies or intolerance to milk, soy, or palm oil

Conditions6

DiabetesInsulin ResistanceMetabolic DiseaseObesityPreDiabetesType 2 Diabetes

Locations1 site

University of Michigan
Ann Arbor, Michigan, 48109

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