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Effects of Different Oxygen Concentrations on Pulmonary Complications in Patients Undergoing Radical Resection of Esophageal Cancer

RECRUITINGPhase 4Sponsored by China Medical University, China
Actively Recruiting
PhasePhase 4
SponsorChina Medical University, China
Started2023-09-06
Est. completion2025-09-30
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted

Summary

Radical operation of esophageal cancer is complicated and traumatic, and ventilation with one lung in lateral position and ventilation with both lungs after supine position requires long-term tracheal intubation and ventilator-assisted ventilation, and the incidence of postoperative pulmonary complications is high.

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* American Association of Anesthesiologists (ASA) patients with I-II physical condition;
* Patients with preoperative partial pressure of blood gas and oxygen greater than 80mmHg who were scheduled for elective esophageal cancer surgery were operated in the right lateral position first and then in the supine position.

Exclusion Criteria:

* there is a history of acute lung injury with acute respiratory distress syndrome within three months;
* Heart failure (classified by new york Heart Association) is greater than grade IV,
* there is a serious liver and kidney dysfunction (children with grade B or C liver failure, glomerular filtration rate \< 30 ml/min);
* Body mass index \> 30kg/m2;
* coagulation dysfunction;
* Operation time exceeds 10h
* The amount of bleeding is more than 800ml, and the total fluid volume is more than 3000ml.

Conditions3

Atelectasis, PostoperativeCancerLung Cancer

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