CCT for Comprehensive Risk Stratification Following STEMI

Summary

The CT-STEMI study aims to evaluate a comprehensive cardiac computed tomography (CCT) protocol for assessing the risk of heart failure (HF), life-threatening arrhythmias (LTA), and atherothrombotic events following ST-elevation myocardial infarction (STEMI). This multicenter, prospective study has three main objectives: 1. Comparing the diagnostic accuracy of the comprehensive CCT protocol with cardiac magnetic resonance (CMR), considered the non-invasive gold standard. 2. Determining the prognostic value of CCT in assessing myocardial tissue adverse features related to STEMI. 3. Evaluating the atherosclerotic burden in patients with post-acute STEMI. Two hundred patients will undergo both CCT and CMR in the post-acute phase, and their follow-up will focus on monitoring HF, LTA, and ischemic events. The CT-STEMI study represents the first attempt to assess the potential of CCT in providing a comprehensive risk assessment following STEMI in a large contemporary population. The findings of this study have the potential to revolutionize post-STEMI risk stratification practices.

Eligibility

Inclusion Criteria:

* Signed informed consent
* STEMI diagnosis
* Primary Percutaneous Coronary Intervention (PCI) \<24h from symptom onset
* Hemodynamic stability without inotropic support within 4 days from the index event

Exclusion Criteria:

* Known chronic kidney disease with estimated Glomerular Filtration Rate (GFR) \< 30 mL/min/1.73mq
* History of allergic reaction to CCT or CMR contrast media
* Inability or unwilling to undergo CCT or CMR scanning
* Pregnancy or breast-feeding
* Severe atrial or ventricular arrhythmia burden
* Severe valvular stenosis or regurgitation
* Prior clinical congestive HF diagnosis (asymptomatic LV dysfunction can be included)

Conditions2

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