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Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis

RECRUITINGSponsored by IRCCS San Raffaele
Actively Recruiting
SponsorIRCCS San Raffaele
Started2021-09-20
Est. completion2024-09-30
Eligibility
Age18 Years+
Healthy vol.Accepted

Summary

The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis. Specific aims are: 1) identify mitochondrial-related pathways, inherited and somatic mitochondrial DNA mutations associated to primary progressive multiple sclerosis, 2) functionally assess the identified genetic alterations.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patients affected by primary progressive or relapsing remitting multiple sclerosis
* Patient able to provide informed consent

Exclusion Criteria:

* Individuals with \< 18 years
* Patients not affected by primary progressive or relapsing remitting multiple sclerosis

Conditions1

Multiple Sclerosis

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