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COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion

RECRUITINGSponsored by Ruijin Hospital
Actively Recruiting
SponsorRuijin Hospital
Started2010-01-01
Est. completion2025-12-31
Eligibility
Age18 Years – 90 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06054126

Summary

A severe coronary artery obstruction is a prerequisite for spontaneous collateral recruitment. The formation of coronary collateral circulation(CCC) is significantly impaired in type 2 diabetic patients with chronic total occlusion (CTO) compared with non-diabetic patients with CTO. This retrospective cohort enrolls consecutive T2DM patients who had at least one lesion with coronary angiographic total occlusion.

Eligibility

Age: 18 Years – 90 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age 18-90 years
* Type 2 diabetes diagnosed by one of the following criteria:

HbA1c \>/= 6.5% Fasting plasma glucose \>/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT \>/= 11.1 mmol/l Already receiving glucose-lowering agents.

* At least one lesion with angiographic total occlusion

Exclusion Criteria:

* eGFR\<15mL/(min·1.73m2)
* chronic heart failure with NYHA grade ≥3
* had a history of coronary artery bypass grafting
* had received a percutaneous coronary intervention within the prior 3 months
* Malignant tumor or immune system disorders
* Pulmonary heart disease

Conditions4

Chronic Total Occlusion of Coronary ArteryDiabetesDiabetes Mellitus, Type 2Heart Disease

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