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Somatic Mosaicism in Twins Discordant for Childhood Cancer

RECRUITINGSponsored by Children's Oncology Group
Actively Recruiting
SponsorChildren's Oncology Group
Started2024-06-03
Est. completion2026-06-30
Eligibility
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06054295

Summary

Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* Newly diagnosed patient with CNS tumor or have recurrent disease and enrolled on APEC14B1.
* Patient must have same sex twin. Note: (history of) treatment on a COG therapeutic trial is not required.
* Patients must be diagnosed at \< 19 years of age at the time of diagnosis.
* A family is eligible to participate if the twin with the CNS tumor is deceased but has a blood sample banked through APEC14B1.
* All patients and/or their parents or legal guardians must provide informed consent. Assent will be obtained for participants between the ages of 8-17 years.
* All institutional, FDA, and NCI requirements for human studies must be met.

Conditions5

CancerCentral Nervous System TumorDiscordant TwinPediatric Central Nervous System TumorSomatic Mutation

Locations1 site

University of Minnesota
Minneapolis, Minnesota, 55455
Jenny Poynter, PhD612-625-4232poynt006@umn.edu

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