Effect of Timed-Restricted Eating on Metabolic Health

Summary

We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin resistance.

Eligibility

Inclusion Criteria:

* Ability to provide informed consent;
* BMI \> 30kg/m\^2;
* Insulin resistance, as defined by fasting plasma insulin \> 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose \> 5.3 and \< 7.0 mmol/L;
* Stable weight for 3 months prior to study inclusion
* For women, 1 year after last menstrual cycle

Exclusion Criteria:

* Use of any medication, except for those related to treatment of metabolic syndrome;
* Any medical condition interfering with study outcomes or design;
* History of any psychiatric disorder, including eating disorders;
* Performing shift work
* Performing intensive sports (\>3 hours/week);
* Smoking;
* Drugs abuse or alcohol abuse (\>3 units/day);
* Contraindication for MRI;
* Known lactose/gluten intolerance;
* Known soy, egg, milk or peanut allergy;
* Childhood onset of obesity

Conditions4

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