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Effect of Anti-inflammatory Diet in Osteoarthritis

RECRUITINGN/ASponsored by University of California, San Diego
Actively Recruiting
PhaseN/A
SponsorUniversity of California, San Diego
Started2023-10-01
Est. completion2026-01-01
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06080347

Summary

In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Unilateral radiographic symptomatic KOA
* No changes in therapy during the previous 3 months
* Interested in dietary intervention and able to provide consent and attend follow-up visits

Exclusion Criteria:

* Previous knee surgery
* Severe radiographic disease (KL grade 4)
* Rheumatoid Arthritis
* Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges)
* Use of corticosteroids and/or intra-articular injections during the preceding 3 months
* Use of fish oils and glucosamine
* Participation in a weight loss program in the preceding 6 months
* Recent changes in physical activity levels
* Regular smoking
* Patients with food allergies
* Patient with other medical conditions that will impair the ability to participate in a nutritional study
* Plan to change systemic therapy
* Patients unwilling to change dietary habits

Conditions2

ArthritisOsteoarthritis, Knee

Locations1 site

University of California
San Diego, California, 92122
Monica Guma, M.D, PHDmguma@health.ucsd.edu

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