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Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment

RECRUITINGSponsored by Tianjin Huanhu Hospital
Actively Recruiting
SponsorTianjin Huanhu Hospital
Started2023-11-01
Est. completion2026-11-01
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06090682

Summary

This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

1\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS.

Exclusion Criteria:

Exclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.

Conditions3

Cognitive ImpairmentParkinson DiseaseParkinson's Disease

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