Role of Inhaled Nitric Oxide in Vascular Mechanics and Right Ventricular Function

Summary

The aim of this study is to evaluate the role of nitric oxide on pulmonary vasculature and right ventricular function in postoperative cardiac surgery patients.

Eligibility

* Age \> 18 years
* Under controlled mechanical ventilation in passive conditions
* Presence of postoperative lung collapse (confirmed by pulmonary echocardiography and Air test)
* Preoperative left ventricular ejection fraction (LVEF) ≥ 30%.
* Absence of hypovolemia: absence of "kissing" ventricles and/or collapsibility index of the superior vena cava \< 20%.
* Stable spontaneous heart rhythm
* Postoperative hemodynamic stability:
* Mean arterial pressure (MAP) ≥ 60 mmHg
* Central venous pressure (CVP) ≥ 10 mmHg
* Heart rate (HR) ≤ 100 bpm without tachyarrhythmias
* Lactic acid ≤ 3 mmol/L
* Single vasopressor treatment
* Norepinephrine dose ≤ 0.2 μg/kg/min, without an increase ≥ 15% in the last 30 -minutes.

Obtained informed consent

Conditions3

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