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PEPPI Study: Identification of Women at Risk for Placental Dysfunction

RECRUITINGSponsored by Oulu University Hospital
Actively Recruiting
SponsorOulu University Hospital
Started2022-02-15
Est. completion2027-12-31
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06115122

Summary

The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a Finnish general population. Condition or disease: pre-eclampsia, intrauterine growth restriction, polycystic ovary syndrome

Eligibility

Healthy volunteers accepted
Mothers

Inclusion Criteria for PEPPI-study

* Pregnant (first trimester)
* Understands Finnish
* ≥18 years
* Signed informed consent

Exclusion Criteria

* Multiple pregnancy
* Miscarriage/termination of the index pregnancy
* No first trimester blood sampling

Inclusion Criteria for FERPPI-study

* Participates in PEPPI-study (criteria above)
* Blood samples at first and third trimester of pregnancy
* Permits blood sampling from the umbilical cord when the baby is born

Exclusion Criteria

* No first or third trimester blood sampling
* No umbilical cord blood sample after baby is born

Fathers

Inclusion Criteria

* Biological father to the child born for the mother who participated in PEPPI study
* ≥18 years
* Signed informed consent

Exclusion Criteria

• Does not understand Finnish

Children

Inclusion Criteria for PEPPI-study

* Born to mother who participated in PEPPI study
* Signed informed consent from parent(s)

Exclusion Criteria

• No consent from parent(s)

Inclusion Criteria for PEPPI-offspring study • Mother in risk-, control-, or PCOS group during PEPPI-study with ultrasound information at gestational weeks 30-32 or a mother who developed pre-eclampsia during the pregnancy regardless of their study group during PEPPI-study

Exclusion Criteria

• Mother/father declines participation

Inclusion Criteria for FERPPI-study

* Signed informed consent from parent(s)
* Mother has blood samples taken at first and third trimester (iron status)
* Child has blood samples taken at birth and at 3 months of age

Exclusion Criteria

* No consent from parent(s)
* No blood samples from mother
* No blood samples from child

Conditions8

CancerCardiovascular DiseasesHypertensive Disorder of PregnancyIntrauterine Growth RestrictionIron-deficiencyPolycystic Ovary SyndromePre-EclampsiaProteinuria in Pregnancy

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