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Androgens and NAFLD Longitudinal Cohort Study

RECRUITINGSponsored by University of California, San Francisco
Actively Recruiting
SponsorUniversity of California, San Francisco
Started2024-01-22
Est. completion2028-12
Eligibility
Age18 Years – 42 Years
SexFEMALE
Healthy vol.Accepted
Locations2 sites
View on ClinicalTrials.gov →

NCT06124261

Summary

The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can cause damage to the liver such as inflammation or scarring. Young women with a condition called polycystic ovary syndrome (PCOS) have a high risk for NAFLD, and they often have high androgen levels too. So the researchers are recruiting young women with PCOS as well as those without PCOS, and will compare changes in NAFLD over time between young women with and without PCOS. This study is funded by the National Institutes of Health

Eligibility

Age: 18 Years – 42 YearsSex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* Metabolic associated steatohepatitis (MASH) (formerly NASH)
* PCOS
* Non-PCOS

Exclusion Criteria:

* High levels of alcohol use (more than 7 drinks a week)
* Current pregnancy
* Other causes of hepatic steatosis
* Weight loss of more than 10% body weight in the last 6 months

Conditions4

Liver DiseaseNAFLDNASHPCOS

Locations2 sites

California

1 site
University of California San Francisco
San Francisco, California, 94143
Elle K Oberweis-Manion, B.A.415-502-3725elle.oberweismanion@ucsf.edu

North Carolina

1 site
Duke University
Durham, North Carolina, 27708
Linda Perry, R.N.linda.blalock@duke.edu

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