Profiles of Expression in HPV+ Versus HPV Head and Neck Cancers

Summary

Squamous cell cancers of the head and neck are classically correlated to excessive consumption of alcohol and tobacco and have a rather poor prognosis. However, the incidence of Head and Neck cancers in patients without alcohol-smoking risk factor has continued to increase in recent years, in relation to more and more frequent HPV contamination. Some studies show a difference in the expression of certain genes within the two groups of tumors (HPV+ and HPV-) including some that confer sensitivity to certain chemotherapies and others to radiotherapy. However, patients with HPV+ Head and Neck cancers are treated according to the same referential as HPV- Head and Neck cancers. There is therefore a real need for studies identifying predictive markers in order to be able to offer patients a more effective suitable and less invasive treatment.

Eligibility

Inclusion Criteria:

* Patient with oropharyngeal squamous cell carcinoma or the oral cavity histologically proven.
* Primary tumor for which a biopsy or excision is required available and sufficient to carry out molecular analysis

Exclusion Criteria:

\- Patient with Head and Neck cancer other than oropharyngeal or oral cavity squamous cells carcinomas

Conditions2

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