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A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

RECRUITINGPhase 3Sponsored by Mayo Clinic
Actively Recruiting
PhasePhase 3
SponsorMayo Clinic
Started2024-04-01
Est. completion2028-06-01
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06150560

Summary

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* B/S1 hypertension
* SBP 100-139 average based on 3 office measurements.
* Age 18 or Older
* Previous COA Repair

Exclusion Criteria:

* Currently on beta blocker (BB) therapy
* Pregnancy/lactating
* eGFR\<30
* Hyperkalemia (serum potassium \>5.5mmol/L)
* Severe Aortic or Mitral valve stenosis or regurgitation
* Epicardial CAD diagnosis
* Received antihypertensive medications within the past year

Conditions3

Coarctation of AortaHeart DiseaseHigh Blood Pressure

Locations1 site

Mayo Clinic in Rochester
Rochester, Minnesota, 55905
ACHD Research Program(507) 293-2565RSTACHDRESPRG@mayo.edu

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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