Rotational Thromboelastometry [ROTEM] vs Thromboelastography [TEG] Guided Blood Component Use in Patients With Cirrhosis of Liver With Non-variceal Bleeding.

Summary

This study is aim to compare ROTEM and TEG guided coagulopathy correction in cirrhosis with non- variceal bleed.There are no other study in literature to compare this two group in cirrhosis with non-variceal bleed.This study will also assess the volume of blood product transfused with this two groups and it will compare among two groups.This will lessen the blood product transfusion and risk of transfusion relatedated complication.

Eligibility

Inclusion Criteria:

1. Patients with Cirrhosis of any etiology
2. Age between 18 and 80 years;
3. Presenting with nonvariceal upper GI bleeding (diagnosed after doing upper GI endoscopy, which showed ongoing
4. bleed form a nonvariceal source); and
5. Significant coagulopathy assessed by CCTs (INR \> 1.8 and/or PLTs \< 50 × 109/L).

Exclusion Criteria:

1. Variceal bleed
2. Post Variceal ligation ulcer bleed
3. Previous or current thrombotic events defined as any documented blood clot in a venous or arterial vessel;
4. Anti-PLT or anticoagulant therapy at the time of enrollment or that had been discontinued less than 7 days before evaluation for the study;
5. Pregnancy
6. Significant cardiopulmonary diseases.

Conditions2

Browse More Trials