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Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation

RECRUITINGN/ASponsored by Barts & The London NHS Trust
Actively Recruiting
PhaseN/A
SponsorBarts & The London NHS Trust
Started2024-08-02
Est. completion2026-03-01
Eligibility
Age18 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06165510

Summary

A randomised controlled clinical trial to assess efficacy of convergent ablation with the LARIAT procedure, as compared to standard endocardial catheter ablation in patients with long-standing persistent atrial fibrillation (AF).

Eligibility

Age: 18 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age \> 18 years; \< 80 years
* Persistent AF \> 1-year duration
* Left atrium size \< 6cm
* Pts should be able to provide written informed consent.

Exclusion Criteria:

* Subjects currently enrolled in another investigational study except in case of observational registry with no associated treatments.
* Subject has a reversible cause of AF or transient AF
* Subject is absent of LAA or if the LAA is previously surgically ligated
* Subject has had previous cardiac surgery or abdominal surgery.
* Subject has contraindication to anticoagulation.
* Patients with hypertrophic cardiomyopathy.
* Patients with significant valve disease.
* Subject has had previous catheter or surgical ablation

Conditions5

Atrial ArrhythmiaAtrial Fibrillation, PersistentAtrium; FibrillationHeart DiseasePersistent Atrial Fibrillation

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