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LSM and SSM for the Diagnosis of CSPH: a Prospective Cohort Study

RECRUITINGSponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre
Actively Recruiting
SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre
Started2024-01-10
Est. completion2028-12
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06181409

Summary

The goal of this observational study is to assess non-invasive tools' efficacy in predicting portal hypertension-related complications in individuals with advanced chronic liver disease. The main question it aims to answer are: \- what are the cut-off values for non-invasive tests (NITs) (including LSM, SSM) that predict the presence and occurrence of hepatic decompensation in individuals with advanced chronic liver disease? Participants will undergo regular study visits involving non-invasive tests (LSM, SSM) and assessments to monitor hepatic decompensation over the study period.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age above 18years old
* Advanced chronic liver disease (defined as LSM ≥ 10kPa)
* Ability to provide informed consent

Exclusion Criteria:

* Transjugular intrahepatic portosystemic shunt
* previous liver transplantation
* Abnormality of the porto-mesenteric system (portal vein thrombosis, splenic vein thrombosis, splenectomy, portal cavernomatous transformation, porto-caval shunts)
* Hematological malignancy

Conditions2

Advanced Chronic Liver DiseaseLiver Disease

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