Hitting the Mark: Introducing State-of-the-art MRI for Precision Radiotherapy of Glioblastoma

Summary

The goal of this prospective cohort study is to assess the potential of advanced MRI for improved radiotherapy target delineation in patients diagnosed with glioblastoma. The main questions it aims to answer are: * How does the coverage of the recurrence volume by a radiotherapy plan based on advanced MRI compare to the coverage by the clinical radiotherapy plan? * How does the distribution of the dose to organs at risk by a radiotherapy plan based on advanced MRI compare to the distribution by the clinical radiotherapy plan? Participants will undergo an extended MRI-protocol prior to radiotherapy. This extended MRI-protocol includes the clinical brain tumor imaging protocol plus additional advanced MRI-sequences. Radiation treatment and patient follow-up will occur according to the clinical standard.

Eligibility

Inclusion Criteria:

* Written informed consent;
* Adult (18 years or older);
* Diagnosed with IDH-wildtype glioblastoma, as confirmed by pathology including molecular analysis post resection/biopsy;
* Referred to the outpatient clinic of the Dept. of Radiotherapy to undergo standard treatment with radiotherapy (30x2 Gy or 15x2.67Gy or 10x3.4Gy).

Exclusion Criteria:

* Contraindication for (3 Tesla) MRI;
* Contraindication for use of gadolinium-based contrast agent (e.g. subject having renal deficiency or known allergy);
* Referred for treatment of recurrent glioblastoma;
* Previous radiotherapy to the brain;
* Unable to give informed consent

Conditions2

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