|

Effect of Gastrectomy on Gut Microbiome and Cognitive Function

RECRUITINGSponsored by Jiangjiang Bi
Actively Recruiting
SponsorJiangjiang Bi
Started2024-01-20
Est. completion2025-12
Eligibility
Age40 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06186089

Summary

Perioperative neurocognitive disorders is a common postoperative complication in elderly surgical patients. The role of gut microbiota in cognitive function has been concerned in recent years. Studies suggests that gastrointestinal surgery may affect the gut microbiota, and the effect varies between surgical procedures. In this study, the investigators will compare the differences of gut microbiota between total gastrectomy and double-tract reconstruction, to investigate the effect of gastric acid on the gut microbiota colonizing, and the effect of different surgical procedures on the postoperative cognitive function of proximal gastric cancer patients.

Eligibility

Age: 40 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

1. Clinical diagnosis of proximal gastric cancer and will be performed gastrectomy
2. American Society of Anesthesiologists (ASA) classification I-III
3. Aged 40-80 years
4. Perioperative consciousness

Exclusion Criteria:

1. Central nervous system and psychological disorders
2. Chronic use of sedatives, antidepressants within the last year
3. Parkinson's disease
4. Severe immunosuppression
5. Severe hearing or vision impairment
6. Drug dependence; alcoholism
7. Inability to communicate with a physician

Conditions3

CancerGastric CancerPerioperative Neurocognitive Disorders

Browse More Trials

Cancer trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.