Impact of Gravity on Cardiac Hemodynamics

Summary

The goal of this clinical trial is to define and compare pre-load dependance of the cardiac function according to the intracardiac hydrostatic gradient of pressure in healthy and diabetic populations. Participants will undergo 4 tilt angle and 4 lower body negative pressure intensities during which cardiovascular data will be assessed and a transthoracic echography will be performed.

Eligibility

Inclusion Criteria:

* Affiliated to the social security system
* Patient informed of the study and having signed an informed consent form
* Type 1 diabetes for at least 10 years followed at Caen University Hospital, equipped with a continous glucose monitoring system

Exclusion Criteria:

* Trained athletes (≥ 6 hours of sustained physical exercise \>70% VO2max per week for \> 6 months)
* Chronic cardiovascular disease or cardiovascular treatment
* Personal history of chemotherapy and/or thoracic radiotherapy
* Cerebral and/or spinal disease
* Inclusion of the subject in another biomedical research protocol of interventional type (during the study or in the 3 months prior to inclusion)
* Pregnant, breast-feeding or parturient women
* Adults under legal protection (guardianship, curators) or unable to express their consent or deprived of their freedom

Conditions4

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