A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

Summary

The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.

Eligibility

Inclusion Criteria:

* Be within the ages of 18 and 70 years of age
* Speak English as their primary language
* Confirmed MS diagnosis by a neurologist
* Be relapse and steroid-free for at least 30 days
* Mild-to-moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS)
* Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ)
* Right handedness

Exclusion Criteria:

* History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression)
* Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q)
* Currently use medications that may impact cognition (ex: steroids, benzodiazepines)
* Currently pregnant
* Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe)
* Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)

Conditions1

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