Cinnamon and COH in PCOS Women Underdoing IVF/ICSI Cycles

Summary

In patients with polycystic ovary syndrome, insulin resistance increases, and since the extracts from cinnamon reduces insulin resistance by two mechanisms (1- increasing activation of the IRS/PI-3 kinase insulin signaling pathway and 2- stimulate auto phosphorylation of the insulin receptor and inhibit protein tyrosine phosphatase I). Through these two mechanisms cinnamon extract make adipocytes to increase the glucose uptake and glycogen synthesis. So this hypothesis arises that it can be effective in improving the symptoms of polycystic ovary syndrome.

Eligibility

Inclusion Criteria:

* Infertile women with polycystic ovary syndrome (PCOS) diagnosed according to the Rotterdam criteria who meet at least 2 of the following three criteria including: (1) oligomenorrhea or anovulation, (2) hyperandrogenism (clinical or biochemical ng/ dL 80 ≤ serum T level), (3) the presence of polycystic ovaries in ultrasound).
* The age range of 18 to 38 year.
* Written consent to participate in the study

Exclusion Criteria:

* Body mass index above 35 kg/m2
* Chronic and Endocrine disorders including diabetes mellitus, hyperprolactinemia, hypertension, Cushing's syndrome
* Autoimmune disorders
* History of recurrent pregnancy loss
* Genital, ovarian or uterine abnormalities
* Hydrosalpinx diagnosis
* Congenital adrenal hyperplasia, androgen-producing tumors or acromegaly
* Sensitivity to cinnamon
* Daily and frequent consumption of cinnamon to treat infertility
* Severe male factor infertility
* Moderate to severe endometriosis diagnosis Use of other hypoglycemic, insulin-sensitizing drugs (e.g. Metformin) or other antioxidant supplement (e.g. Myo-inositol) and β-blocker before or during the study

Conditions2

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