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EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

RECRUITINGSponsored by Virginia Commonwealth University
Actively Recruiting
SponsorVirginia Commonwealth University
Started2024-12-26
Est. completion2028-03
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06212791

Summary

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age ≥18 years
* Diagnosis of paroxysmal AF
* Left ventricular ejection fraction ≥50%
* Scheduled for catheter ablation
* Able to speak, hear, and read English
* Willing and able to provide informed consent

Exclusion Criteria:

* Persistent or permanent AF
* Prior ablation (catheter based or surgical) for AF
* Significant sinus node dysfunction
* Implanted pacemaker or defibrillator
* Contraindication to or inability to complete cardiovascular magnetic resonance study
* Contraindication to or inability to complete exercise testing
* Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2
* Severe left ventricular hypertrophy
* Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to:

  * Hypertrophic cardiomyopathy
  * Cardiac amyloidosis
  * Constrictive pericarditis
* Pulmonary arterial hypertension
* Prior cardiac surgery
* Active pregnancy

Conditions2

Heart DiseaseParoxysmal Atrial Fibrillation

Locations1 site

Virginia Commonwealth University
Richmond, Virginia, 23298
Pamela Grizzard804-628-6234pamela.grizzard@vcuhealth.org

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