|

Cortical Electrophysiology of Response Inhibition in Parkinson's Disease

RECRUITINGPhase 4Sponsored by Emory University
Actively Recruiting
PhasePhase 4
SponsorEmory University
Started2021-08-09
Est. completion2026-07-31
Eligibility
Age45 Years – 75 Years
Healthy vol.Accepted
Locations2 sites
View on ClinicalTrials.gov →

NCT06234995

Summary

Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions.

Eligibility

Age: 45 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria for Persons with Parkinson's Disease for Aim 1:

* diagnosis of idiopathic Parkinson's disease (PD)
* Hoehn and Yahr (H\&Y) stage 2-4 (off medication)

Exclusion Criteria for Persons with Parkinson's Disease for Aim 1:

* severe tremor at rest or severe dyskinesia which would cause significant artifacts in electrophysiological signals
* inability to hold antiparkinsonian medications for research recordings
* dementia
* non-English speaker

Inclusion Criteria for Persons with Parkinson's Disease for Aim 2:

* diagnosis of idiopathic PD
* there is a clinical indication for DBS surgery
* normal preoperative MRI
* ability to tolerate microelectrode-guided neurosurgery in an awake state

Exclusion Criteria for Persons with Parkinson's Disease for Aim 2:

* presence of a coagulopathy
* uncontrolled hypertension
* heart disease
* other medical conditions considered to increase the patient's risk for surgical complications

Inclusion Criteria for Persons with Parkinson's Disease for Aim 3:

* diagnosis of idiopathic PD
* functioning DBS system

Exclusion Criteria for Persons with Parkinson's Disease for Aim 3:

* severe tremor at rest or severe dyskinesia which would cause significant artifacts in electrophysiological signals
* inability to hold antiparkinsonian medications for research recordings
* inability to tolerate temporary discontinuation of DBS therapy or alteration of stimulation settings for research purposes
* other medical conditions considered to increase the patient's risk for surgical complications

Inclusion Criteria for Healthy Controls:

* age 45-75

Exclusion Criteria for Healthy Controls:

* history of a neuropsychiatric disorder and/or treatment with psychotropic medications
* non-English speaker

Conditions2

Parkinson DiseaseParkinson's Disease

Locations2 sites

Emory University Hospital
Atlanta, Georgia, 30322
Emory Brain Health Center
Atlanta, Georgia, 30329

Browse More Trials

Parkinson's Disease trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.