Studies of Phenotypic and Functional Characteristics of Circulating Neutrophil Subpopulations in Patients With Lung Cancer

Summary

The objective is to study the phenotypic, functional and metabolomic characteristics of neutrophils circulating subpopulations in lung cancer patients, and to compare them to a control group of healthy volunteers. A blood sample will be taken before the first treatment session for the lung cancer patient and a second blood sample will be taken during the first evaluation visit. The investigators hypothesize that there may be different circulating neutrophil subpopulations in patients with metastatic non-small cell lung cancer (NSCLC) involved in tumor progression and resistance to immunotherapy.

Eligibility

Inclusion Criteria common to lung cancer and COPD patients :

* Age ≥ 18 years,
* male or female,
* affiliated with a Health Insurance,

Inclusion Criteria for lung cancer patients :

\- Diagnosis of metastatic stage lung cancer with mutation status, naïve treatment

Inclusion Criteria for COPD patients :

\- Diagnosis of COPD post-smoking

Exclusion Criteria:

* Tuberculosis or other acute or chronic bacterial infections
* Chronic progressive viral infections (Hepatitis B and C, HIV)
* Previous or ongoing chemotherapy
* Impossibility of giving the subject informed information.
* Opposition to the research.
* Participation in another research study with an exclusion period still in progress at pre-inclusion (possible inclusion in an observational study)
* Vulnerable individual (pregnant, parturient or breastfeeding woman), persons under guardianship or curatorship, or deprived of liberty by a judicial or administrative decision)
* Patients benefiting from the AME

Conditions2

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