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Generation of Organotypic Liver Cultures for the Identification of Biomarkers for the Prevention and Treatment of Liver Fibrosis

RECRUITINGN/ASponsored by Regina Elena Cancer Institute
Actively Recruiting
PhaseN/A
SponsorRegina Elena Cancer Institute
Started2023-01-17
Est. completion2025-01-17
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06252272

Summary

Low-level, interventional, biological and non-pharmacological study prospective intervention for the preparation of organotypic human liver slice cultures Liver Slice Culture (hLSC) applying the protocol described by Jiang and collaborators.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* age over 18 years old;
* patients for whom it is indicated to undergo abdominal surgery for tumors primary or secondary liver diseases;
* patients who express informed consent to the study.

Exclusion Criteria:

* medical contraindication to performing a liver biopsy;
* liver cirrhosis;
* macroscopic signs of chronic liver disease;
* moderate or severe steatosis;
* cholestasis;
* hepatic necrosis.

Conditions2

Hepatic FibrosisLiver Disease

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