Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients

Summary

Current guidelines recommend the inititaion of noradrenaline and if shock is refractory, then vasopressin should be administered. Data indicate that the earlier use of vasopressin may improve survival. Two large randomized controlled trial failed to prove a survival benefit from the early use of vasopressin. The present study will investigate the effect of an early initiation protocol of vasopressin (as the first vasoconstrictor drug) on the degree of multiorgan failure improvement and also on the course of sepsis (if in septic patients) versus early initiation of noradrenaline as first vasoconstrictor drug in hemodynamically unstable patients.

Eligibility

Inclusion Criteria:

• Shock (mean arterial pressure \<65 mmHg) after initial resuscitation with fluids

Exclusion Criteria:

* Patients under 18 years of age.
* Known heart failure (ejection fraction \&lt;35%)
* Recent acute myocardial infarction
* Pulmonary embolism

Conditions2

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