Effects of a Combined Exercise Intervention on the Gut Microbiome of People With Type 2 Diabetes

Summary

The goal of this experimental trial is to learn about the changes in bacterial diversity in individuals with type 2 diabetes who perform endurance and strength training at different intensities. Participants with type 2 diabetes will be randomly assigned to 16 weeks of either moderate-intensity endurance and strength training or high-intensity endurance and strength training. Researchers will compare the moderate-intensity and high-intensity exercise groups for differences in glycemia and bacterial diversity.

Eligibility

Inclusion Criteria:

* Adults aged 19 - 64 years old;
* Diagnosed with type 2 diabetes;
* An HbA1c \>= 7.0%;
* Not currently meeting the recommended levels of physical activity for optimal health (i.e., 150 minutes of moderate-to-vigorous physical activity and 2+ days/week of resistance training);
* Average less than 10,000 steps per day over the last seven days;
* No change in diabetes medications over the last three months.

Exclusion Criteria:

* Not diagnosed with type 2 diabetes;
* Partaking in a self-reported regular exercise regimen, defined as consistent participation in running or jogging activity, attending exercise classes every week, or averaging 10,000 steps per day or more over seven days;
* Currently performing two days of resistance training per week;
* Having an injury that would prevent safe participation in the intervention;
* A self-reported diagnosis of low iron concentrations, anemia, or being treated for these conditions;
* A diagnosis of any red blood cell altering condition (i.e., sickle cell anemia, poikilocytosis);
* Currently living with any cardiovascular disease which would impact the ability to participate in exercise safely;
* Currently prescribed any medication which would impact the ability to use a heart rate monitor to accurately track intensity.

Conditions2

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