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Tumor Microenvironment in Ovarian Cancer

RECRUITINGSponsored by University of Udine
Actively Recruiting
SponsorUniversity of Udine
Started2024-01-02
Est. completion2024-07
Eligibility
Age18 Years – 80 Years
SexFEMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06272240

Summary

A detailed understanding of molecular mechanism of cancer genesis is fundamental to develop innovative and personalized therapies. The new frontier in biomedical research is represented by organoids, a three-dimensional cell culture system obtained from a tissue fragment that accurately reproduces the essential properties of the original tissue in vitro, which could provide a valuable model for explanation of ovarian cancers pathogenesis and will allow to predict the response to a specific therapy. With this research project, we expect to generate ovarian cancer organoids to characterize in vitro interactions and molecular pathway among tumor cells, immune cells, and resident microbiota (intratumoral bacteria and/or microbial-derived molecules).

Eligibility

Age: 18 Years – 80 YearsSex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* Age \> 18 years
* Age \< 80 years
* Serous ovarian carcinoma
* FIGO Stage III-IV

Exclusion Criteria:

* Ongoing or suspended immunosuppressive therapy within the last 6 months
* Congenital or acquired immunodeficiency
* Immunosuppressive state
* Administration of chemotherapy for another neoplasm in the past 12 months
* Non-epithelial ovarian tumors
* Patients not undergoing surgical intervention
* BMI \> 30
* Absence of Informed Consent

Conditions3

CancerOvarian Cancer Stage IIIOvarian Cancer Stage IV

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