Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
NCT06273527
Summary
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.
Eligibility
Inclusion Criteria: * age 21-55 * fluent in English * diagnosis of mood, anxiety, or traumatic stress disorder * clinically elevated repetitive negative thinking * outpatient status * 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications Exclusion Criteria: * past year diagnosis of severe alcohol or moderate or greater substance use disorder * lifetime history of psychotic or bipolar I disorder * acute suicidality necessitating immediate clinical intervention * neurodegenerative or neurodevelopmental disorders * history of moderate or severe traumatic brain injury or other known neurological condition * sensory deficits that would preclude completing tasks * conditions unsafe for completing MRI scanning (e.g., metal in body) * current pregnancy * currently receiving psychosocial treatment * currently receiving psychiatric pharmacotherapy, except SSRIs
Conditions4
Locations1 site
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NCT06273527