Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy

Summary

This observational study is to develop and validate the prediction model for functional mitral regurgitation regression in heart failure patients taking GDMT. The patients diagnosed ≥2+ functional mitral regurgitation by ultrasonic cardiogram are enrolled in this study and would be clinically followed by at least one year (clinical visit at 3 months, 6 months, and 12 months), and then by when the endpoints are reached.

Eligibility

Inclusion Criteria:

* Age\>18 years old
* ≥2+ FMR
* Receiving GDMT

Exclusion Criteria:

* degenerative mitral regurgitation
* myocardial infarction, percutaneous coronary intervention, coronary bypass grafting surgery, cardiac resynchronization therapy, or stroke within three months prior to this study
* ≥2+ aortic stenosis or regurgitation
* previous surgical mitral valve repair or replacement
* restrictive cardiomyopthy, hypertrophic cardiomyopathy, or constrictive pericarditis
* severe heart failure (NYHA class IV) or left ventricular ejection fraction \< 20%
* symptomatic hypotension affecting GDMT prescription
* severe hepatic or renal insufficiency
* life expectancy \< 12 months
* Pregnancy

Conditions3

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