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Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

RECRUITINGSponsored by University of Washington
Actively Recruiting
SponsorUniversity of Washington
Started2024-01-02
Est. completion2028-12-31
Eligibility
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06295965

Summary

This study is being done to investigate clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian or other solid cancers. Researchers want to identify risk factors for developing these blood cancers as well as if there is/are a genetic/environmental component(s) to developing blood cancer.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* Subjects who have or have had ovarian, peritoneal, or fallopian tube carcinoma who have a life expectancy of greater than 6 months and:

  * Have completed or plan to complete at least 5 cycles of platinum-based chemotherapy

OR

* Subjects who have or have had a solid tumor diagnosis and any of the following:

  * At least 4 months of exposure to a PARP inhibitor
  * Diagnosis of a blood disorder including, but not limited to, clonal hematopoiesis of indeterminate potential, cytopenia of unknown significance, or therapy-related myeloid neoplasm

Exclusion Criteria:

* Individuals with a life expectancy of less than 6 months

Conditions11

CancerClonal Cytopenia of Undetermined SignificanceClonal HematopoiesisIdiopathic Cytopenia of Undetermined SignificanceMyeloid Neoplasm Post Cytotoxic TherapyNon-Neoplastic Hematopoietic and Lymphoid Cell DisorderOvarian CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Malignant Solid NeoplasmRecurrent Ovarian Carcinoma

Locations1 site

Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, 98109
Swisher Lab Research Coordinators206-616-8927swisherlabrc@uw.edu

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