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Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure

RECRUITINGSponsored by Johns Hopkins University
Actively Recruiting
SponsorJohns Hopkins University
Started2024-12-10
Est. completion2029-03-31
Eligibility
Age18 Years – 90 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06299436

Summary

Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH.

Eligibility

Age: 18 Years – 90 YearsHealthy volunteers accepted
Inclusion Criteria:

* Adult patients aged between 18 and 90 years of age
* Diagnosed with heart failure with reduced ejection fraction (LV ejection fraction ≤ 40-50%)
* Can safely hold direct oral anticoagulant (DOAC) vitamin K antagonist (VKA) for 48 hours prior to the procedure

Exclusion Criteria:

* Unable to interrupt VKA anticoagulation
* Point of care International Normalized Ratio (INR) \> 1.5
* Pregnant patients
* Acute hospitalization or decompensation within 2 weeks prior to study date
* Participation in a study involving an investigational drug within 4 weeks prior to study date
* Inability to lie flat in the supine position
* Symptomatic hemodynamic instability at rest or during the procedure

Conditions4

Heart DiseaseHeart Failure With Reduced Ejection FractionPulmonary HypertensionRight Heart Failure Due to Left Heart Failure

Locations1 site

Johns Hopkins Hospital
Baltimore, Maryland, 21287
Wendy I Foy410-955-8491wfoy2@jh.edu

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