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Potential Correlation Between Heart Rate Variability With Cardiovascular Risk at Different Stages of Metabolic Syndrome

RECRUITINGSponsored by Alexandria University
Actively Recruiting
SponsorAlexandria University
Started2023-08-23
Est. completion2024-09-01
Eligibility
Age18 Years – 70 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06305195

Summary

The study aims to assess the beat-to-beat Heart rate variability (HRV) in different stages of metabolic diseases, including pre-diabetic and diabetic patients, compared to non-diabetic individuals. Heart rate variability will be compared for some antidiabetic drugs used in different stages of metabolic diseases and correlated to different metabolic and inflammatory mediators.

Eligibility

Age: 18 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

1. Non-diabetic individuals: adults (18-70 Years) with glycated hemoglobin (HBA1C)\<5.7 and/or Fasting blood glucose \<100 mg/L and with no classic symptoms of hyperglycemia
2. Pre-diabetic: adults (18-70 Years) who fulfil one of the American Diabetes Association (ADA) criteria :

   * glycated hemoglobin (HBA1C) =5.7-6.4%
   * Fasting blood glucose level = 100 mg/dL to 125 mg/dL. Fasting is defined as no caloric intake for at least 8 hours.
3. Diabetic patients: adults (18-70 Years) who fulfil one of the American Diabetes Association (ADA) criteria:

   * glycated hemoglobin (HBA1C) ≥6.5%
   * Fasting blood glucose ≥126 mg/dL.
   * A random plasma glucose ≥200 mg/dL. Random is any time of the day without regard to the meals.

Exclusion Criteria:

* Pediatric and elderly subjects
* Pregnant subjects
* Those with active Myocardial infarction
* Those with acute decompensated heart failure
* Patients with pacemaker
* Patients with persistent Atrial fibrillation, long-standing persistent and permanent Atrial fibrillation

Conditions3

DiabetesDiabetes MellitusHeart Disease

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