Radiochemotherapy and Interventional Radiotherapy in Vaginal Cancer

Summary

Prospective observational multicenter study, aimed at evaluating the effectiveness on local control and cancer-specific survival of radiochemotherapy followed by interventional radiotherapy in patients affected by vaginal cancer

Eligibility

Inclusion Criteria:

* Age more than18 years old
* Performance status 0,1
* Hystological diagnosis of squamous vaginal cancer
* HPV, p16, p53 status
* Stage I, II, III and IV (AJCC 2018th version)
* Stadiation with magnetic resonance and positron emission tomography
* Informed consensus

Exclusion Criteria:

* Age inferior 18 years old
* Performance status more than 2
* Previous cancer in the last ten years
* Previous radiation treatment in the region of interest
* Presence of pathologies that contraindicate radiotherapy treatment (genetic syndromes of hyper-radiosensitivity, ulcerative colitis, diverticulitis in the acute phase, severe diverticulosis, chronic pelvic inflammation)
* Presence of internal pathologies that contraindicate chemotherapy or radio-chemotherapy treatment (severe liver disease, heart disease, renal failure, etc.)
* Presence of distant metastases in sites other than the pelvic lymph nodes
* Any significant medical condition that in the opinion of the investigator may interfere with the patient's optimal participation in the study

Conditions2

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