In Situ Exploration of Vascular Function in Vasoplegic Shock Following Cardiac Surgery With Cardiopulmonary Bypass

Summary

The goal of this observational study is to assess in situ vascular function, glycocalyx and microcirculation in postoperative vasoplegic shock following cardiac surgery with cardiopulmonary bypass. The main question is to investigate the relationship between NO-dependent vasomotor reserve and the presence of vasoplegic shock following cardiac surgery with cardiopulmonary bypass. Participants will have two visits, during which a number of non-invasive examinations will be carried out to study glycocalyx, microcirculation and vascular function. Biological and morphological data will be collected up to 3 months after inclusion, as well as information on treatments administered and outcome. Researchers will compare a group of patients with vasoplegic shock against a group without vasoplegic shock in order to study possible alterations in function in the vasoplegic shock group.

Eligibility

Inclusion Criteria:

* Patients aged between 18 and 80 years old
* Patient undergoing cardiac surgery with cardiopulmonary bypass
* Hospitalised in a cardiac surgical unit, between 4 and 24 hours after the end of cardiopulmonary bypass, after volemic optimisation

Exclusion Criteria:

* Sepsis at inclusion
* Cardiac transplant
* Circulatory assistance
* Known alteration of the microcirculation
* Any condition contraindicating measurement via Glycocheck or flux mediated dilatation measurement
* New surgery within 48 hours of the operation
* Person deprived of liberty by an administrative or judicial decision or person placed under legal protection / sub-guardianship or guardianship
* Patient refusal

Conditions2

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