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Weight Loss and ExeRcise

RECRUITINGN/ASponsored by VA Office of Research and Development
Actively Recruiting
PhaseN/A
SponsorVA Office of Research and Development
Started2024-05-01
Est. completion2027-12-31
Eligibility
Age40 Years – 80 Years
Healthy vol.Accepted
Locations1 site

Summary

Weight loss interventions for neurologically health individuals have established benefits for improving physical and psychosocial function. The investigators believe that Veterans who have had a stroke would realize similar benefits and that the effects would be enhanced with concurrent exercise training. The investigators will study the effects of a 15-week lifestyle management program to determine if it can effectively improve some of the physical and psychosocial problems common in Veterans who have had a stroke.

Eligibility

Age: 40 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

* A diagnosis of stroke at least 6 months prior
* BMI \> 30 kg/m2
* Residual paresis in the lower extremity (Fugl-Meyer LE motor score \<34)
* Ability to follow instructions, complete training and testing and to communicate exertion, pain and distress
* Provision of informed consent

  * Individuals who meet inclusion criteria must complete an exercise tolerance test and be cleared for participation by the study cardiologist

Exclusion Criteria:

* Unable to ambulate at least 150 feet or experienced intermittent claudication while walking
* Unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's
* Dementia
* Life expectancy \<1 yr
* History of DVT or pulmonary embolism within 6 months
* Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions
* Severe hypertension with systolic \>200 mmHg and diastolic \>110 mmHg at rest
* Current enrollment in a rehabilitation trial to enhance motor or psychosocial recovery

Conditions2

StrokeWeight Loss

Locations1 site

Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, 29401-5703
R. Amanda C LaRue, PhD843-789-6707Rutha.Larue@va.gov

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