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Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics

RECRUITINGN/ASponsored by University of Zurich
Actively Recruiting
PhaseN/A
SponsorUniversity of Zurich
Started2023-06-15
Est. completion2025-06-30
Eligibility
Age18 Years+
Healthy vol.Accepted

Summary

This clinical study examines patients presenting with acute myocardial infarction and no significant coronary artery disease on coronary angiography (MINOCA) and patients with MINOCA-mimics with advanced CMR. The present study aims to: * assess the microvascular function with a novel quantitative 3D myocardial perfusion imaging approach in the acute phase and post-convalescence * refine the role and diagnostic potential of advanced quantitative CMR imaging * assess the potential prognostic significance of microvascular dysfunction and epicardial adipose tissue on cardiovascular outcomes Participants will undergo advanced CMR imaging in the acute setting (within 10 days after event) and post convalescence (after 3 months).

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* acute presentation with signs/symptoms of acute coronary syndrome or myocarditis
* elevated cardiac biomarkers
* no signficant coronary artery disease on coronary angiogram or coronary CT

Exclusion Criteria:

* pacemaker/other devices or claustrophobia
* severe asthma, chronic obstructive lung or kidney disease
* acute pulmonary embolism
* arrhythmia on ECG
* moderate to severe valvular disease

Conditions6

Heart DiseaseMyocardial Infarction With Non-Obstructive Coronary ArteryMyocarditis AcuteNon ST Elevation Myocardial InfarctionSpontaneous Coronary Artery DissectionTakotsubo Cardiomyopathy

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