Microbiota in Gastric Cancer by Gastric Mucosal Brushing

Summary

Many studies have shown a significant change of diversity and composition in gut microbiota across the gastric carcinogenesis process, particularly in patients with gastric cancer. However, there has been no analysis of gastric microbiota using the mucosal brushing technique, despite its favoring benefit in microbiota study. Therefore, this study aims to evaluate microbiota profile in patients with gastric cancer, compared to those without gastric cancer by using mucosal brush sampling. This will improve current knowledge of the potential role of the microbiome in patient gastric cancer as a future biomarker marker using brushing sampling.

Eligibility

Inclusion Criteria:

* Adult patients (≥18 years of age) and undergoing esophagogastroduodenoscopy (EGD)
* Gastric cancer group: patients with pathological diagnosis of high-grade dysplasia or gastric cancer
* Control group: patients with no or minimal upper GI symptoms and current EGD appear normal or minimal gastritis
* Informed consent obtained

Exclusion Criteria:

* Had a history of GI or hepatobiliary surgery
* Had a history of recent (within 4 weeks) antibiotic or probiotic use
* Had a history of PPI use within 2 weeks

Conditions2

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