A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients

Summary

This study aims to investigate the clinical, socioeconomic, behavioral, genetic, and molecular factors characterizing Early Onset Colorectal Cancer (EOCRC) patients compared with Late Onset Colorectal Cancer (LOCRC) patients

Eligibility

Inclusion Criteria:

* Patients aged more than 18 years old at the time of inclusion.
* Patients with a proven diagnosis of colorectal adenocarcinoma, as reported by the staging histological biopsies.
* Patients with a preoperative staging I-III.
* Patients scheduled for elective curative colorectal resection.
* Patients with rectal cancer who underwent neoadjuvant therapy can be included in the study.
* Patients able and willing to comply with the protocol requirements (samples' collection and questionnaires' compilation).

Exclusion Criteria:

* Patients with metastatic disease at diagnosis.
* Patients requiring an emergent procedure.
* Patients undergoing palliative surgery (for example, fecal diversion).
* Patients with a surgical indication for benign lesions (for example, adenoma or dysplasia).
* Patients with an intraoperative finding of a lesion other than adenocarcinoma will be withdrawn from the study.
* Patients with an intraoperative finding of distal metastasis or peritoneal carcinosis will be withdrawn from the study.
* Patients with a concomitant diagnosis of Inflammatory Bowel Disease.
* Patients with a known genetic syndrome (for example, Lynch syndrome or Familial Adenomatous Polyposis).

Conditions2

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