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Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA

RECRUITINGN/ASponsored by Thammasat University Hospital
Actively Recruiting
PhaseN/A
SponsorThammasat University Hospital
Started2024-04-01
Est. completion2025-05-31
Eligibility
Age50 Years – 85 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06328062

Summary

The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty. The main question\[s\] it aims to answer are: • Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty. Participants will randomized to mirogabalin or pregabalin group and will take the drug for 6 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.

Eligibility

Age: 50 Years – 85 YearsHealthy volunteers accepted
Inclusion Criteria:

1. Age 50-85 years old
2. Unilateral primary osteoarthritis undergoing primary TKA
3. ASA I-III

Exclusion Criteria:

1. GFR \<60
2. Allergy to drug in this study
3. Cannot underwent spinal anesthesia and adductor canal block
4. Taking gabapentinoid within 3 months before surgery
5. History of previous knee surgery
6. Severe liver disease

Conditions4

ArthritisOsteoarthritisPain, PostoperativeTotal Knee Arthroplasty

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