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Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis

RECRUITINGSponsored by University of Utah
Actively Recruiting
SponsorUniversity of Utah
Started2024-01-16
Est. completion2026-01
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06329414

Summary

The goal of this single-arm, observational pilot study is to learn about the safety, feasibility, preliminary efficacy of TMS for the treatment of depression in people with MS. Participants will receive outpatient TMS treatment over the course of 5-6 weeks. Participants will complete validated questionnaires and exams before, during, and after treatment.

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* Established diagnosis of multiple sclerosis (any subtype) by 2017 McDonald criteria
* Established diagnosis of major depressive disorder (MDD) by DSM-5 criteria
* Eligible for transcranial magnetic stimulation (rTMS) for depression

Exclusion Criteria:

* MS relapse and/or steroid use within 3 months
* Active suicidal ideation
* History of seizure/epilepsy, brain tumor, or stroke
* History of bipolar disorder or psychosis
* Currently or planning to become pregnant

Conditions4

DepressionMajor Depressive DisorderMultiple SclerosisTreatment-resistant Depression

Locations1 site

University of Utah Health
Salt Lake City, Utah, 84108
Kathleen Shangraw, MD801-583-2500

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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