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Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology

RECRUITINGPhase 2/3Sponsored by M.D. Anderson Cancer Center
Actively Recruiting
PhasePhase 2/3
SponsorM.D. Anderson Cancer Center
Started2024-06-11
Est. completion2030-03-31
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site

Summary

To learn about the effect of Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology (SPOT-ON) treatment on the severity of shortness of breath in patients with cancer.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Diagnosis of advanced cancer (metastatic, locally advanced, recurrent, or incurable).
* Age 18 or older.
* Admitted to a medical floor.
* Dyspnea intensity at rest of at least 4 on a 0-10-point NRS (where 0 = none, 10 = worst).
* Speak English or Spanish.

Exclusion Criteria:

* Hemodynamic instability requiring active Merit Team or ICU team involvement.
* Delirium as per clinical team's assessment in the Electronic Health Record (EHR).
* Severe hypoxemia (SpO2 \< 90% despite supplemental oxygen of up to 6 L/min).
* Continuous positive airway pressure (CPAP) use for obstructive sleep apnea, actively using \>10 hours a day.
* Respiratory failure necessitating mechanical ventilation (i.e., HFNC or NIV), and planned thoracentesis within 72 hours of enrollment.
* Patients with known pregnancy.

Conditions2

CancerDyspnea

Locations1 site

MD Anderson Cancer Center
Houston, Texas, 77030
David Hui, MD713-792-6258dhui@mdanderson.org

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