Ultra-High Frequency Ultrasonography in Sjögren's Syndrome

Summary

Patients diagnosed with a diagnosis of Sjogren's syndrome performed according to the ACR/EULAR criteria will be included in the study. Sjogren's syndrome diagnosis will be performed following a complete diagnostic work-up involving rheumatologic assessment, glandular functional tests, and blood testing for anti-Ro(SSA) antibodies. Conventional ultrasonography of major salivary glands and ultra-high frequency ultrasonography (70 MHz) of minor salivary glands will be performed, and the scans assessed using the Outcome Measures in Rheumatology (OMERACT) scoring system (Score 0 normal glandular tissue, Score 1 mild glandular alteration, fine echogenicity or diffuse hypo-echogenicity, Score 2 moderate glandular alteration and focal hypoechoic areas with partial conservation of normal parenchyma, Score 3 diffuse presence of hypoechoic areas in the absence of normal glandular parenchyma with glandular fibrosis. Focus Score will be assessed following biopsy of minor salivary glands.

Eligibility

Inclusion Criteria:

* adults ≥ 18 years of age
* clinical suspect of Sjogren\'s syndrome
* acceptance to undergo complete Sjogren\'s Syndrome diagnostic work-up
* acceptance to be included in the study.

Exclusion Criteria:

* pregnancy or breastfeeding
* any acute or chronic condition that would limit the ability of the patient to participate in the study
* refusal to give informed consent

Conditions2

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